林口長庚醫院皮膚科 - 藥物過敏中心

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皮膚科

鐘文宏 醫師

 
 

   皮膚科 --鐘文宏 醫師 Wen-Hung Chung, M.D., Ph.D.
 

   現職:

  • 長庚醫院藥物過敏中心主任
  • 長庚醫院學術組教授
  • 長庚醫院皮膚科主任/主治醫師
  • 長庚大學副教授
 

   經歷:

  • 陽明大學生命科學院生化暨分子生物研究所博士
  • 中華民國皮膚科專科醫師
   
     臨床與研究興趣:
 

藥物不良反應、藥物基因體學、免疫學

   

 藥物過敏相關論文發表 :

  1. Yang CYChen CHDeng STHuang CSLin YJChen YJWu CYHung SIChung WH*. Allopurinol Use and Risk of Fatal Hypersensitivity Reactions: A Nationwide Population-Based Study in Taiwan. JAMA Intern Med. 2015 Sep 1;175(9):1550-7. (SCI; IF=13.116; Medicine, General & Internal 8/154)
  2. Chung WHPan RYChu MTChin SWHuang YLWang WCChang JYHung SI*. Oxypurinol-Specific T Cells Possess Preferential TCR Clonotypes and Express Granulysin in Allopurinol-Induced Severe Cutaneous Adverse Reactions. J Invest Dermatol. 2015 May 6. doi: 10.1038/jid.2015.165. [Epub ahead of print] (SCI; IF=5.778; Immunology: 22/144; Infectious diseases: 5/72; Microbiology: 16/119)
  3. Chung WH, Chang WC, Stocker SL, Juo CG, Graham GG, Lee MH, Williams KM, Tian YC, Juan KC, Jan Wu YJ, Yang CH, Chang CJ, Lin YJ, Day RO, Hung SI*. Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and granulysin. Ann Rheum Dis. 2014 Aug 12. (SCI; IF=9.270; Rheumatology 2/30)
  4. Chung WH*, Chang WC, Lee YS, Wu YY, Yang CH, Ho HC, Chen MJ, Lin JY, Hui RCY, Ho JC, Wu WM, ChenTJ, Wu T, WU YR, Hsih MS, TU PH, Chang CN, Hsu CN, Wu TL, Choon SE, Hsu CK, Chen DY, Liu CS, Lin CY, Kaniwa N, Saito Y, Takahashi Y, Nakamura R, Azukizawa H, SHi Y, Wang TH, Chang SS, Tsai SF, Chang CJ, Chang YS, Hung SI*, Taiwan SCAR consortium, and JPDSC. Genetic variants associated with pheytoin-related severe cutaneous adverse reactions. JAMA. 2014 Aug 6;312(5):525-34. (SCI; IF=30.387; Medicine, General & Internal 3/150)
  5. Yang CY, Chen CH, Wang HY, Hsiao HL, Hsiao YH, Chung WH*. Strontium ranelate related Stevens-Johnson syndrome: a case report. Osteoporos Int. 2014 Jun;25(6):1813-6. (SCI; IF=4.165; Endocrinology & Metabolism: 30/123)
  6. Genin E, Chen DP, Hung SI, Sekula P, Schumacher M, Chang PY, Tsai SH, Wu TL, Bellón T, Tamouza R, Fortier C, Toubert A, Charron D, Hovnanian A, Wolkenstein P, Chung WH*, Mockenhaupt M*, Roujeau JC. HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis. Pharmacogenomics J. 2014 Jun;14(3):281-8. (SCI; IF=5.513; Genetics & heredity: 20/164; Pharmacology & pharmacy: 14/254)
  7. Yeh CN, Chung WH, Su SC, Chen YY, Cheng CT, Lin YL, Chang WC, Chung-Yee Hui R, Chiang KC, Chen TW, Jan YY, Chen CW, Chen TJ, Yang CH*, Hung SI*. Fas/Fas Ligand Mediates Keratinocyte Death in Sunitinib-Induced Hand-Foot Skin Reaction. J Invest Dermatol. 2014 May 6. doi: 10.1038/jid.2014.218. (SCI; IF=5.778; Immunology: 22/144; Infectious diseases: 5/72; Microbiology: 16/119)
  8. Lin YF, Yang CH, Sindy H, Lin JY, Rosaline, Hui CY, Tsai YC, Wu TS, Huang CT, Kao KC, Hu HC, Chiu CH, Hung SI, Chung WH*. Severe Cutaneous Adverse Reactions Related to Systemic Antibiotics. Clin Infect Dis. 2014 May;58(10):1377-85. (SCI; IF=9.416; Immunology: 10/144; Infectious diseases: 2/70; Microbiology: 8/119)
  9. Chi MH, Hui RC, Yang CH, Lin JY, Lin YT, Ho HC, Chung WH*, Kuo TT*. Histopathologic Analysis and Clinical Correlation of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). The British journal of dermatology. 2014 Apr;170(4):866-73. (SCI; IF=4.100; Dermatology: 7/61)
  10. Cho YT, Lin JW, Chen YC, Chang CY, Hsiao CH, Chung WH*, Chu CY*. Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features. J Am Acad Dermatol. 2014 Mar;70(3):539-48. (SCI; IF=5.004; Dermatology: 3/61)
  11. Hsiao YH, Hui RC, Wu T, Chang WC, Hsih MS, Yang CH, Ho HC, Chang YG, Chen MJ, Lin JY, Chen DP, Chang PY, Wu TL, Hung SI*, Chung WH*. Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: Strength and clinical correlations. J Dermatol Sci. 2014 Feb;73(2):101-9. (SCI; IF=3.335; Dermatology: 9/61)
  12. Su SC, Chung WH*. Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions. Toxins (Basel). 2014 Jan 3;6(1):194-210. (SCI; IF=2.480; Toxicology: 43/87)
  13. Kao WY, Su CW, Huang YS*, Chou YC, Chen YC, Chung WH*, Hou MC, Lin HC, Lee FY, Wu JC. Risk of Oral Anti-fungal Agent-Induced Liver Injury in Taiwanese. Br J Clin Pharmacol. 2014 Jan; 77(1):180-9. (SCI; IF=3.688; Pharmacology & pharmacy: 50/254)
  14. Lee YY, Ko JH, Chung WH*. Acute generalized exanthematous pustulosis induced by levetiracetam. Int J Dermatol. 2014 Jan;53(1):e5-6. (SCI; IF=1.227; Dermatology: 42/61)
  15. Chung WH, Shih SR, Chang CF, Lin TY, Huang YC, Chang SC, Liu MT, Ko YS, Deng MC, Liau YL, Lin LH, Chen TH, Yang CH, Ho HC, Lin JW, Lu CW, Lu CF, Hung SI*. Clinicopathologic analysis of coxsackievirus A6 new variant induced widespread mucocutaneous bullous reactions mimicking severe cutaneous adverse reactions. J Infect Dis. 2013 Dec 15;208(12):1968-78. (SCI; IF=5.778; Immunology: 22/144; Infectious diseases: 5/70; Microbiology: 16/119)
  16. Lee HY*, Chung WH. Toxic epidermal necrolysis: the year in review. Curr Opin Allergy CLin Immunol. 2013 Aug; 13(4):330-6. (SCI; IF=3.659; Allergy: 6/21; Immunology: 48/144)
  17. Hu CH, Chang NJ, Liu EK, Chuang SS, Chung WH, Yang JY*. SCORTEN and impaired renal function related to mortality of toxic epidermal necrolysis syndrome patients in the Asian population. J Eur Acad Dermatol Venereol. 2013 May; 27(5): 628-33. (SCI; IF=3.105; Dermatology: 10/61)
  18. Hung SI, Chung WH*. Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore. Neurology. 2013 Apr 23;80(17):1621-2. Neurology. 2013 Apr 23;80(17):1621. (SCI; IF=8.303; Clinical Neurology: 8/194)
  19. Lin YT, Chang YC, Hui R CY, Yang CH, Hung SI, Chung WH*. A patch testing and cross-sensitivity study of carbamazepine-induced severe cutaneous adverse drug reactions. J Eur Acad Dermatol Venereol. 2013 Mar;27(3):356-64. (SCI; IF=3.105; Dermatology: 10/61)
  20. Wei CY, Chung WH, Huang HW, Chen YT, Hung SI*. Direct interaction between HLA-B and carbamazepine activates T cells in Stevens-Johnson syndrome. J Allergy Clin Immunol. 2012 Jun;129(6):1562-9. (SCI; IF=11.248; Allergy: 1/21; Immunology: 8/144)
  21. Chung WH*, Hung SI. Recent advances in the genetics and immunology of Stevens-Johnson syndrome and toxic epidermal necrosis. J Dermatol Sci. 2012 Apr 11. 66(3): 190-6. (SCI; IF=3.335; Dermatology: 9/61)
  22. Yang CY, Dao RL, Lee TJ, Lu CW, Yang CH, Hung SI, Chung WH*. Severe cutaneous adverse reactions to antiepileptic drugs in Asians. Neurology. 2011 Dec 6;77(23):2025-33. (SCI; IF=8.303; Clinical Neurology: 8/194)
  23. Ko TM, Chung WH, Wei CY, Shih HY, Chen JK, Lin CH, Chen YT, Hung SI*. Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. J Allergy Clin Immunol. 2011 Dec;128(6):1266-1276. (SCI; IF=11.248; Allergy: 1/21; Immunology: 8/144)
  24. Wei CH, Hui RCY, Chang CJ, Ho HC, Yang CH, Lin YJ, Chung WH*. Identifying prognostic factors for drug rash with eosinophilia and systemic symptoms (DRESS). Eur J Dermatol. 2011 Nov-Dec;21(6):930-7. (SCI; IF=1.953; Dermatology: 20/61)
  25. Chen P, Lin JJ, Lu CS, Ong CT, Hsieh PF, Yang CC, Tai CT, Wu SL, Lu CH, Hsu YC, Yu HY, Ro LS, Lu CT, Chu CC, Tsai JJ, Su YH, Lan SH, Sung SF, Lin SY, Chuang HP, Huang LC, Chen YJ, Tsai PJ, Liao HT, Lin YH, Chen CH, Chung WH, Hung SI, Wu JY, Chang CF, Chen L, Chen YT*, Shen CY; Taiwan SJS Consortium. Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med. 2011 Mar 24;364(12):1126-33. (SCI; IF=54.42; Medicine, general & internal: 1/150)
  26. Phillips EJ*, Chung WH, Mockenhaupt M, Roujeau JC, Mallal SA. Drug hypersensitivity: pharmacogenetics and clinical syndromes. J Allergy Clin Immunol. 2011 Mar;127:S60-6. (SCI; IF=11.248; Allergy: 1/21; Immunology: 8/144)
  27. Chung WH, Hung SI*. Genetic markers and danger signals in Stevens-Johnson syndrome and toxic epidermal necrolysis. Allergol Int. 2010 Dec;59(4):325-32. Epub 2010 Oct 25. (non-SCI)
  28. Hung SI, Chung WH, Liu ZS, Chen CH, Hsih MS, Hui RCY, Chu CY, Chen YT*. Common risk allele in aromatic anti-epileptic-drugs induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics. 2010 Mar;11(3):349-56. (SCI; IF=3.425; Pharmacology & pharmacy: 59/254)
  29. Chung WH, Hung SI, Chen YT*. Genetic predisposition of life-threatening antiepileptic-induced skin reactions. Expert Opin Drug Saf. 2010 Jan;9(1):15-21. (SCI; IF=2.735; Pharmacology & pharmacy: 93/254)
  30. Lin WL, Lin WC, Chang YC, Yang LC, Hung SI, Hong HS, Chung WH*. Intravenous immunoglobulin-induced, non-eczematous, vesiculobullous eruptions in Stevens-Johnson syndrome. Am J Clin Dermatol. 2009;10(5):339-42. (SCI; IF=2.519; Dermatology: 12/61)
  31. Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC, Yang CH, Lu CF, Wu JY, Liao YD, Chen YT*. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med. 2008 Dec;14(12):1343-50. (SCI; IF=28.054; Biochemistry & molecular biology: 2/291; Cell biology: 3/185; Medicine, research & experimental: 1/122)
  32. Chiou CC, Yang LC, Hung SI, Chang YC, Kuo TT, Ho HC, Hu S, Hong HS, Chung WH*. Clinicopathological features and prognosis of drug rash with eosinophilia and systemic symptoms: a study of 30 cases in Taiwan. J Eur Acad Dermatol Venereol. 2008 Sep;22(9):1044-9. (SCI; IF=3.105; Dermatology: 10/61)
  33. Lin WL, Lin WC, Yang JY, Hung SI, Chung WH*. Fatal Toxic Epidermal Necrolysis Associated With Cetuximab in a Colon Cancer Patient. J Clin Oncol. 2008 Jun 1;26(16):2779-80. (SCI; IF=17.879;Oncology: 5/202)
  34. Chung WH, Hung SI, Chen YT*. Human leukocyte antigens and drug hypersensitivity. Curr Opin Allergy Clin Immunol. 2007 Aug;7(4):317-323. (SCI; IF=3.659; Allergy: 6/21; Immunology: 48/144)
  35. Chung WH , Hung SI, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT*. Genetic susceptibility to carbamazepine- induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. (SCI; IF=3.45; Biotechnology & applied microbiology: 39/165; Genetics & heredity: 56/164; Pharmacology & pharmacy: 56/254)
  36. Chiou CC, Chung WH*. Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection. J Am Acad Dermatol. 2006 Feb;54(2):S14-7. (SCI; IF=5.004; Dermatology: 3/61)
  37. Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, Lin YL, Lan JL, Yang LC, Hong HS, Chen MJ, Lai PC, Wu MS, Chu CY, Wang KH, Chen CH, Fann CS, Wu JY, Chen YT*. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Nat Acad Sci U S A. 2005; 102(11):4134-9. (SCI; IF=9.809; Multidisciplinary sciences: 4/55)
  38. Hung SI, Chung WH, Chen YT*. HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine. Personalized Medicine 2005; 2(3): 225-237. (SCI; IF=1.132; Pharmacology & pharmacy: 196/254)
  39. Chung WH, Hung SI, Hong SH, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT*. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004; 428(6982):486. (SCI; IF=42.351; Multidisciplinary sciences: 1/55)